Living Tissue Technology

Bioengineered Skin - Apligraf & Dermagraft Living Cellular Products

FDA-approved living skin substitutes containing human fibroblasts and keratinocytes for diabetic foot ulcers and venous leg ulcers. Apligraf and Dermagraft bioengineered skin grafts deliver growth factors, cytokines, and extracellular matrix proteins that promote rapid wound closure when standard treatments fail. Medicare Part B covered mobile wound care in Beverly Hills, Orange County, Los Angeles, and all Southern California.

What Are Bioengineered Skin Substitutes?

Bioengineered skin substitutes are living tissue-engineered products that contain viable human cells (fibroblasts and/or keratinocytes) within a biocompatible matrix. These products mimic the structure and function of normal human skin.

Unlike traditional wound dressings, bioengineered skin actively participates in wound healing by secreting growth factors, cytokines, and extracellular matrix proteins that stimulate tissue regeneration and accelerate closure.

Living Cells

Contains viable human fibroblasts and keratinocytes

FDA Approved

Rigorous clinical trials prove safety and efficacy

Medicare Covered

Reimbursed for qualifying chronic wounds

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85%+ Healing Rate

In clinical studies

FDA-Approved Bioengineered Skin Products

Apligraf

Bi-layered living skin equivalent with both dermal and epidermal layers

Dermagraft

Cryopreserved human fibroblast-derived dermal substitute

Epifix / Grafix

Dehydrated human amnion/chorion membrane grafts

Oasis

Porcine small intestinal submucosa extracellular matrix

Integra

Bilayer wound matrix for dermal regeneration

Theraskin

Split-thickness skin allograft with living cells

How Bioengineered Skin Works

1

Cell Delivery

Living cells applied directly to wound bed

2

Growth Factor Release

Cells secrete proteins that stimulate healing

3

Matrix Formation

Scaffold supports new tissue development

4

Wound Closure

Host cells integrate graft and close wound

Ideal Wounds for Bioengineered Skin

  • Diabetic foot ulcers that have failed 4+ weeks of standard care
  • Venous leg ulcers non-responsive to compression therapy
  • Pressure ulcers (Stage 3 or 4) with adequate blood flow
  • Surgical dehiscence or non-healing post-surgical wounds
  • Burns requiring dermal regeneration

Could Bioengineered Skin Help Your Wound?

Our specialists will evaluate if you're a candidate for living tissue therapy

Schedule Evaluation